Abstract | BACKGROUND: METHODS: A pilot study was conducted to examine the efficacy of an innovative CHG-impregnated postoperative dressing in reducing the burden of methicillin-resistant Staphylococcus aureus (MRSA) in an in vivo porcine, incisional- wound model. Sutured incisional wounds were contaminated with MRSA and then covered with a CHG wound dressing, a placebo control, or a nonantimicrobial gauze. The surviving MRSA population was quantitatively cultured 3 days postprocedure. RESULTS: MRSA was not recovered from any of the 8 wounds that were treated with the CHG dressing (limit of detection, approximately 1.7 log10 colony-forming units [cfu]/g tissue). In contrast, the average microbial recovery from wounds treated with the placebo dressing was 4.2 log10 cfu/g and the average microbial recovery from wounds treated with the gauze dressing was 3.2 log10 cfu/g. CONCLUSIONS: An innovative CHG dressing provided significant antimicrobial activity against MRSA contaminating a surgical wound in a porcine, incisional- wound model. Future clinical studies are needed to assess the efficacy of the CHG dressing to reduce the bacterial burden in postoperative wounds of surgical patients.
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Authors | Thriveen Sankar Chittoor Mana, Curtis Donskey, Neal Carty, Larry Perry, David Leaper, Charles E Edmiston Jr, |
Journal | American journal of infection control
(Am J Infect Control)
Vol. 47
Issue 9
Pg. 1048-1052
(09 2019)
ISSN: 1527-3296 [Electronic] United States |
PMID | 31277998
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Infective Agents, Local
- Placebos
- chlorhexidine gluconate
- Chlorhexidine
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Topics |
- Animals
- Anti-Infective Agents, Local
(administration & dosage)
- Bandages
- Chlorhexidine
(administration & dosage, analogs & derivatives)
- Colony Count, Microbial
- Disease Models, Animal
- Female
- Methicillin-Resistant Staphylococcus aureus
(isolation & purification)
- Pilot Projects
- Placebos
(administration & dosage)
- Postoperative Care
(methods)
- Staphylococcal Infections
(microbiology, prevention & control)
- Surgical Wound Infection
(microbiology, prevention & control)
- Swine
- Treatment Outcome
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