A Comparison of Angiogenesis and Glycolytic Imaging in Patients With Clinical Suspected Locally Advanced Breast Cancer.

Abstract

F-FDG PET/CT imaging is an important diagnostic tool for accurate staging and assessment of response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast carcinoma (LABC). However, F-FDG being non-specific marker, it also accumulates in inflammatory conditions, leading to false positive results. Angiogenesis, an essential characteristic for tumor development, intrusion and metastasis can be imaged using Ga-labeled RGD tripeptide. We here depict a series of clinically staged LABC patients who underwent both Ga-DOTA-RGD2 and F-FDG PET/CT imaging for staging and illustrate the similarities and significant differences between the two tracers.

• Authors: Rakhee Vatsa, Abhiram Gopalajois Ashwathanarayana, Gurpreet Singh, Anwin Joseph Kavanal, Sunil Kumar, Nivedita Rana, Jaya Shukla, Bhagwant Rai Mittal
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 44 Issue 8 Pg. e479-e483 (Aug 2019) ISSN: 1536-0229 [Electronic] United States
• PMID: 31274628 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Fluorodeoxyglucose F18

Topics

• Breast Neoplasms (blood supply, diagnostic imaging, metabolism, pathology)
• Female
• Fluorodeoxyglucose F18
• Glycolysis
• Humans
• Middle Aged
• Neoplasm Staging
• Neovascularization, Pathologic (diagnostic imaging)
• Positron Emission Tomography Computed Tomography