Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties.

Abstract

An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.

• Authors: Ana I Carbajo-Gordillo, Julio Rodríguez-Lavado, José Luis Jiménez Blanco, Juan M Benito, Christophe Di Giorgio, Itziar Vélaz, Concepción Tros de Ilarduya, Carmen Ortiz Mellet, José M García Fernández
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 55 Issue 57 Pg. 8227-8230 (Jul 11 2019) ISSN: 1364-548X [Electronic] England
• PMID: 31268107 (Publication Type: Journal Article)

Chemical References

• Surface-Active Agents
• Trehalose

Topics

• Animals
• Cell Line
• Chlorocebus aethiops
• Humans
• Mice
• Nanostructures (chemistry)
• Plasmids (chemistry, metabolism)
• Surface-Active Agents (chemistry)
• Transfection (methods)
• Trehalose (chemistry)