Abstract |
Plasma carnitine deficiency (41% of normal control) was found in a 9 year-old boy with lysinuric protein intolerance. Following oral carnitine administration, the plasma level of lysine as well as carnitine has significantly increased (p less than 0.05). His well-being seemed to have improved on this substitutive remedy. Hitherto unrevealed these findings on LPI indicate that carnitine has a lysine-sparing effect and suggest that there might be a biosynthetic pathway of carnitine directly from free lysine in human.
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Authors | G Takada, A Goto, K Komatsu, R Goto |
Journal | The Tohoku journal of experimental medicine
(Tohoku J Exp Med)
Vol. 153
Issue 4
Pg. 331-4
(Dec 1987)
ISSN: 0040-8727 [Print] Japan |
PMID | 3126568
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Amino Acid Metabolism, Inborn Errors
(diet therapy, metabolism)
- Carnitine
(administration & dosage, blood, deficiency)
- Child
- Humans
- Lysine
(blood, deficiency, urine)
- Male
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