Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy.

Abstract

Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.

• Authors: Birgit Linhart, Raphaela Freidl, Olga Elisyutina, Musa Khaitov, Alexander Karaulov, Rudolf Valenta
• Journal: Nutrients (Nutrients) Vol. 11 Issue 7 (Jun 29 2019) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 31261965 (Publication Type: Journal Article, Review)

Chemical References

• Allergens
• Biomarkers
• Milk Proteins
• Immunoglobulin E

Topics

• Allergens
• Biomarkers (blood)
• Humans
• Immunoglobulin E (blood)
• Milk Hypersensitivity (diagnosis, immunology, prevention & control, therapy)
• Milk Proteins (adverse effects, immunology)
• Molecular Diagnostic Techniques
• Phenotype
• Predictive Value of Tests
• Treatment Outcome