Abstract |
Studies investigating the association between transforming growth factor (TGF-β-509C/T, rs1800469) promoter polymorphism and myocardial infarction (MI) risk reported inconsistent results. The aim of our study was to assess the association between the 509C/T polymorphism of the TGF-β gene (rs1800469) and MI risk.A total of 5460 cases and 8413 controls in 7 case-control studies were incorporated in our current meta-analysis. The original studies were selected through searching the databases of the PubMed and EMBASE. The odds ratio (OR) and 95% confidence interval (95% CI) of TGF-β 509C/T (rs1800469) for MI risk were applied to estimate the strength of the association.Our results showed that T allele carriers had a 13% increased risk of MI, when compared with the C allele carriers (OR = 1.13, 95% CI: 1.00-1.27). In the subset analysis by the type of MI, significantly elevated risk of MI was associated with the homozygote TT and heterozygote C/T in no-AMI subjects, when compared with the CC homozygote carriers (OR = 1.12, 95% CI:1.02-1.23).Our meta-analysis shows that the polymorphism with homozygote TT and heterozygote C/T of TGF-β 509C/T (rs1800469) is significantly associated with the increased risk of MI.
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Authors | Ling Du, Tao Gong, Minghui Yao, Henghua Dai, Hong Gang Ren, Haitao Wang |
Journal | Medicine
(Medicine (Baltimore))
Vol. 98
Issue 26
Pg. e15946
(Jun 2019)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31261499
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Transforming Growth Factor beta
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Topics |
- Genetic Predisposition to Disease
- Humans
- Myocardial Infarction
(genetics)
- Polymorphism, Single Nucleotide
- Transforming Growth Factor beta
(genetics)
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