Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS).

Abstract

BACKGROUND:

Faecal microbiome transplantation (FMT) appears to be an effective method for treating irritable bowel syndrome (IBS) patients. However, it is not clear if a high transplant dose and/or repeating FMT are/is needed to ensure a response. The present study was undertaken to clarify this matter.

METHODS:

Ten IBS patients who did not respond to a 30-g transplant subsequently received a 60-g transplant into the duodenum via a gastroscope. The patients provided faecal samples before and 1 month after FMT. They completed five questionnaires measuring symptoms, fatigue and quality of life at baseline and then at 2 weeks, 1 month and 3 months after FMT. The dysbiosis index (DI) was measured using the GA-map Dysbiosis Test®.

RESULTS:

Seven patients (70%) responded to the 60-g transplant, with significant clinical improvements in the abdominal symptoms, fatigue and quality of life in 57%, 80% and 67% of these patients. The 60-g transplant also reduced the DI.

CONCLUSION:

FMT is an effective treatment for IBS. A high-dose transplant and/or repeated FMT increase the response rate and the intensity of the effects of FMT.

• Authors: Magdy El-Salhy, Trygve Hausken, Jan Gunnar Hatlebakk
• Journal: Nutrients (Nutrients) Vol. 11 Issue 6 (Jun 24 2019) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 31238507 (Publication Type: Clinical Trial, Journal Article)

Topics

• Adult
• Dysbiosis
• Fecal Microbiota Transplantation (adverse effects)
• Feces (microbiology)
• Female
• Gastrointestinal Microbiome
• Humans
• Irritable Bowel Syndrome (diagnosis, microbiology, therapy)
• Male
• Quality of Life
• Retreatment
• Time Factors
• Treatment Outcome