Alopecia areata is a chronic relapsing autoimmune inflammatory hair disorder with no novel
therapy. The objectives of this study are to compare the efficacy of topical
calcipotriol vs narrow band ultraviolet B
phototherapy (NB-UVB) in the treatment of
alopecia areata and its correlation with serum
vitamin D3 levels. A randomized-controlled trial has been conducted on 60 patients with scalp
alopecia areata randomized into four groups; topical
calcipotriol, NB-UVB, both and placebo. All patients were evaluated by assessment of severity of
alopecia areata by severity of
alopecia tool (
SALT) score at baseline and 3 months
after treatment and
vitamin D3 levels at baseline and after 3 months.
SALT score and
vitamin D3 levels were significantly improved in all groups except placebo
after treatment with (P = 0.026, P = 0.005, P = 0.004, P = 0.140) and (P = 0.028, P = 0.011, P = 0.003, P = 0.725), respectively. Combined
therapy showed non-significant improvement in
SALT score (P = 0.530, P = 0.643), respectively, and significant improvement in serum
vitamin D3 levels than each line alone with (P = 0.021, P = 0.044), respectively. Both topical
calcipotriol and NB-UVB are effective
therapies in the treatment of AA and associated with improvement of
SALT score and
vitamin D3 levels.