Abstract |
Lentigo maligna (LM) is treated to prevent progression to lentigo maligna melanoma (LMM). Surgery is the gold standard but an alternative treatment is off-label topical imiquimod. The aim of this study was to evaluate the effectiveness of 5% topical imiquimod treatment for lentigo maligna. In the period 2007-2017 57 patients with lentigo maligna were treated with off-label topical imiquimod once daily for 12 weeks. Complete clinical clearance was observed in 48 patients (84.2%) and partial clearance in 3 patients (5.3%). Three patients (5.3%) showed no response and another 3 patients (5.3%) stopped treatment due to side-effects. After 4.5 years during follow-up one patient developed a lentigo maligna melanoma which was subsequently excised. Treatment with topical imiquimod resulted in complete clearance of lentigo maligna in 48 out of 57 patients (84.2%). Topical imiquimod is an acceptable treatment option for patients with lentigo maligna who prefer topical treatment to surgery or radiotherapy.
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Authors | Darryl C K S Tio, Catherine van Montfrans, Claire G H Ruijter, Rick Hoekzema, Marcel W Bekkenk |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 99
Issue 10
Pg. 884-888
(Sep 01 2019)
ISSN: 1651-2057 [Electronic] Sweden |
PMID | 31233181
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Imiquimod
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Topics |
- Administration, Cutaneous
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Female
- Humans
- Hutchinson's Melanotic Freckle
(drug therapy, pathology)
- Imiquimod
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Off-Label Use
- Remission Induction
- Retrospective Studies
- Skin Neoplasms
(drug therapy, pathology)
- Time Factors
- Treatment Outcome
- Young Adult
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