Albumin-Encapsulated Platinum Nanoparticles for Targeted Photothermal Treatment of Glioma.

Abstract

Brain tumors are hard to cure due to the life-threatening impact on the vital function areas of brain plus the blood-brain barrier caused poor drug delivery to brain. In this study, we utilized the human serum albumin (HSA) as a template to synthesize ultrasmall platinum nanoparticle for targeted photothermal treatment of glioma. The HSA-encapsulated platinum nanoparticle (HSA-Pt) possessed uniform size and shape, and represented excellent photothermal effect. As an endogenous protein in blood, HSA endowed HSA-Pt great biocompatibility and prolonged blood circulation time. In a subcutaneous model, HSA-Pt accumulated more in tumors than the control nanoparticle due to its long circulation time, resulting in more efficient photothermal regression of tumors. Furthermore, in an orthotropic glioma model, HSA-Pt was able to penetrate the blood-brain barrier and target to glioma, and the tumors were significantly suppressed by photothermal therapy. This study suggests HSA-Pt associated targeted photothermal therapy can be used for the treatment of brain tumors.

• Authors: Chuan Chang, Changping Wang, Chengcheng Zhang, Lin Li, Qiang Zhang, Quan Huang
• Journal: Journal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 15 Issue 8 Pg. 1744-1753 (Aug 01 2019) ISSN: 1550-7033 [Print] United States
• PMID: 31219025 (Publication Type: Journal Article)

Chemical References

• Albumins
• Platinum

Topics

• Albumins
• Cell Line, Tumor
• Glioma
• Humans
• Metal Nanoparticles
• Platinum