Effect of trabeculectomy on corneal endothelial cell loss.

Abstract

AIM:

To investigate changes in corneal endothelial cell density (CECD) after trabeculectomy.

METHODS:

This prospective, observational study followed 117 eyes of 117 patients for 2 years after trabeculectomy. The central cornea was examined by corneal specular microscopy prior to and at every 6 months after the surgery. Survival analysis of patients who exhibited a 10% or less reduction of the postoperative CECD compared with preoperative levels was assessed using the Kaplan-Meier survival curve. A Cox proportional hazards model was used to evaluate prognostic factors for decreasing CECD.

RESULTS:

At baseline, the mean CECD was 2420±357 cells/mm2, while at 6, 12, 18 and 24 months after surgery, the mean CECD was 2324±373 cells/mm2 (p<0.001), 2276±400 cells/mm2 (p<0.001), 2290±398 cells/mm2 (p<0.001) and 2267±446 cells/mm2 (p<0.001), respectively. At 6, 12, 18 and 24 months after surgery, the results of the Kaplan-Meier survival analysis of the 10% loss of CECD from baseline were 91%, 85%, 83% and 77%, respectively. Uveitic glaucoma was a significant prognostic factor for decreasing CECD (p=0.041).

CONCLUSIONS:

CECD significantly and continuously decreased after trabeculectomy.

• Authors: Kazuyuki Hirooka, Eri Nitta, Kaori Ukegawa, Shino Sato, Yoshiaki Kiuchi
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 104 Issue 3 Pg. 376-380 (03 2020) ISSN: 1468-2079 [Electronic] England
• PMID: 31201168 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Topics

• Aged
• Cell Count
• Corneal Endothelial Cell Loss (diagnosis, etiology)
• Endothelium, Corneal (pathology)
• Female
• Follow-Up Studies
• Glaucoma (physiopathology, surgery)
• Humans
• Intraocular Pressure (physiology)
• Male
• Postoperative Complications
• Prognosis
• Retrospective Studies
• Trabeculectomy (adverse effects)
• Visual Acuity