Influence of PSK (Krestin) on resistance to infection of Pseudomonas aeruginosa in tumor-bearing mice.

Abstract

C3H/He mice were inoculated with Pseudomonas aeruginosa by various routes 1 day after X5563 transplantation or 4 days after cyclophosphamide (CY) administration. Administration of PSK (Krestin) i.p. or p.o. to the tumor-bearing mice or CY-treated tumor-bearing mice resulted in an increase in survival rates. Viable P. aeruginosa were inoculated i.v. on day 0 into mice inoculated with tumor cells on day -12 and vaccinated with killed P. aeruginosa on day -10, or into mice inoculated with tumor cells on day -15, treated with CY on day -14 and vaccinated on day -10. Resistance to infection, which is enhanced by vaccination, was depressed by tumor burden or treatment with CY, but such depression was prevented by PSK administration.

• Authors: T Ando, I Motokawa, K Sakurai, Y Ohmura, T Fujii, K Matsunaga, C Yoshikumi, K Nomoto
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 20 Issue 3 Pg. 198-202 ( 1987) ISSN: 0344-5704 [Print] Germany
• PMID: 3119242 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antibodies, Bacterial
• Bacterial Vaccines
• Proteoglycans
• polysaccharide-K
• Cyclophosphamide

Topics

• Adjuvants, Immunologic (administration & dosage, therapeutic use)
• Agglutination Tests
• Animals
• Antibodies, Bacterial (analysis)
• Bacterial Vaccines (administration & dosage)
• Cyclophosphamide (therapeutic use)
• Female
• Granulocytes
• Kidney (microbiology)
• Leukocyte Count
• Mice
• Mice, Inbred C3H
• Plasmacytoma (drug therapy, immunology, mortality)
• Proteoglycans (administration & dosage, therapeutic use)
• Pseudomonas Infections (prevention & control)
• Pseudomonas aeruginosa (immunology, isolation & purification)
• Time Factors