The effect of three different solutions on preventing oral mucositis in cancer patients undergoing stem cell transplantation: a non-randomized controlled trial: A Turkish study - NON-RANDOMISED TRIAL.

Abstract

OBJECTIVE:

To evaluate the effect of different solutions administered to patients undergoing stem cell transplantation on oral mucositis.

METHODS:

The non-randomised controlled trial was conducted at a Istanbul Medipol Mega university hospital in Turkey between May 2014 and June 2016, and comprised patients undergoing stem cell transplantation. They were divided into three groups. Group 1 had patients using chlorhexidine gluconate and benzydamine hydrochloride solution. Group 2 had those using calcium and phosphate solution. Group 3 patients were using black mulberry syrup. Data was collected using a structured questionnaire and the World Health Organisation mucositis assessment scale. Assessment was done on days 7, 14 and 21. Clinical significance of oral solutions was statistically determined.

RESULTS:

Of the 83 patients, 30(36%) were in group 1, 28(34%) in group 2, and 25(30%) in group 3. On day 7, there was no significant difference in terms of grades among the groups (p>0.05). On day 14, grade 2 mucositis was seen in 2(8%) patents in group 3, 5(17.9%) in group 2 and 5(16.7%) in group 1; Grade 3 mucositis was seen in 2(6.7%) patients in group 1, but none in the other two groups. On day 21, grade 3 mucositis was present in 2(8.0%) in group 3, 2(7.1%) in group 2, and 4(13.3%) in group 1.

CONCLUSIONS:

The use of black mulberry and calcium-phosphate solutions was found to be beneficial in preventing and treating oral mucositis.

• Authors: Merve Harman, Nimet Ovayolu, Ozlem Ovayolu
• Journal: JPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 69 Issue 6 Pg. 811-816 (Jun 2019) ISSN: 0030-9982 [Print] Pakistan
• PMID: 31189287 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Pharmaceutical Solutions
• Phosphates
• Plant Extracts
• Benzydamine
• chlorhexidine gluconate
• Chlorhexidine

Topics

• Adolescent
• Adult
• Aged
• Benzydamine (therapeutic use)
• Chlorhexidine (analogs & derivatives, therapeutic use)
• Female
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Male
• Middle Aged
• Morus
• Neoplasms (therapy)
• Pharmaceutical Solutions (therapeutic use)
• Phosphates (therapeutic use)
• Plant Extracts (therapeutic use)
• Stomatitis (drug therapy)
• Turkey
• Young Adult