Abstract |
Recent data on acute lymphoblastic leukemia (ALL) treatment with multi-agent chemotherapy showed excellent response in pediatric patients in terms of long-term survival; however, the clinical needs for adult patients are still unmet. Adolescent and young adults' (AYA) ALL could benefit from a pediatric-inspired regimen with a higher rate of long-term remission. This retrospective study sought to investigate the efficacy of treatment of adult ALL in a single center over the past decade. We analyzed 107 ALL patients with a median age of 26 years (range 15-63 years). Of these, 67.3% received adult regimen and 32.7% received pediatric-inspired regimen. The median follow-up time was 11.6 months (range 1-120). Complete remission (CR) was similarly achieved in over 80% in both schemes. Relapse and refractory rates were higher in the adult group (75%) than in the pediatric (45.7%) group. Two-year disease-free survival in the pediatric group was significantly superior to the adult group (47.1% vs 24.7%, hazard ratio [HR], 1.73, 95% CI 1.22-3.03). Two-year overall survival was higher in pediatric group as compared to adult group (50.8% versus 31.2%, HR 1.52, 95% CI 0.83-2.78). Thus, these findings show that the pediatric-inspired regimen should be considered for the treatment of adult ALL.
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Authors | Adisak Tantiworawit, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada |
Journal | International journal of hematology
(Int J Hematol)
Vol. 110
Issue 3
Pg. 295-305
(Sep 2019)
ISSN: 1865-3774 [Electronic] Japan |
PMID | 31161483
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Vincristine
- Dexamethasone
- Doxorubicin
- Cyclophosphamide
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Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Cyclophosphamide
(administration & dosage)
- Dexamethasone
(administration & dosage)
- Disease-Free Survival
- Doxorubicin
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(drug therapy, mortality)
- Remission Induction
- Retrospective Studies
- Survival Rate
- Vincristine
(administration & dosage)
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