Somatic and germline sequencing in genitourinary oncology: genetics for the clinician.

Abstract

PURPOSE OF REVIEW:

Next-generation sequencing is becoming more accessible. This review focuses on the clinical application of somatic and germline sequencing to genitourinary oncology.

RECENT FINDINGS:

Germline variants have been increasingly recognized as contributing to the development of genitourinary malignancies, particularly in patients with advanced disease. A variety of commercial and institutional technologies are in use to detect variants, with newer tools focused on integrating these results into the clinical workflow.

SUMMARY:

DNA sequencing is becoming a valuable tool in caring for patients with genitourinary malignancies. Performing both somatic and germline sequencing will likely become standard practice. Interpretation and clinical application of these results can be challenging and often requires multidisciplinary expertise.

• Authors: Jonathan E Shoag, David R Wise, Ravi N Sharaf, Cora N Sternberg
• Journal: Current opinion in urology (Curr Opin Urol) Vol. 29 Issue 4 Pg. 315-318 (07 2019) ISSN: 1473-6586 [Electronic] United States
• PMID: 31158105 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Circulating Tumor DNA

Topics

• Circulating Tumor DNA (genetics)
• Germ-Line Mutation
• High-Throughput Nucleotide Sequencing
• Humans
• Sequence Analysis, DNA (methods)
• Urogenital Neoplasms (genetics)