Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis.

Abstract

Circular RNAs (circRNAs) have recently been reported to play crucial roles in various regulatory processes and involved in cancer onset and progression. However, the potential mechanism of circRNAs in chronic lymphocytic leukemia (CLL) remains largely unknown. Here, we observed hsa_circ_0132266 (circ_0132266), a circRNA significantly decreased in the peripheral blood mononuclear cells (PBMCs) of CLL patients compared with healthy donors, could act as an endogenous sponge of hsa-miR-337-3p (miR-337-3p) and regulate its activity, which resulted in a downstream change of target-gene PML and a consequent influence on cell viability. Taken together, our data indicated the regulatory mechanism of circ_0132266 in CLL progression through circ_0132266/miR-337-3p/PML axis, suggesting that it may serve as a biomarker as well as an exploitable therapeutic target for CLL.

• Authors: Wei Wu, Zijuan Wu, Yi Xia, Shuchao Qin, Yue Li, Jiazhu Wu, Jinhua Liang, Li Wang, Huayuan Zhu, Lei Fan, Jianxin Fu, Wei Xu, Hui Jin, Jianyong Li
• Journal: Aging (Aging (Albany NY)) Vol. 11 Issue 11 Pg. 3561-3573 (06 01 2019) ISSN: 1945-4589 [Electronic] United States
• PMID: 31152142 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MicroRNAs
• Mirn337 microRNA, human
• RNA, Circular

Topics

• Cell Survival (physiology)
• Down-Regulation
• Gene Expression Regulation, Neoplastic
• Humans
• Leukemia, Lymphocytic, Chronic, B-Cell (genetics, metabolism)
• Leukocytes, Mononuclear (metabolism)
• MicroRNAs (genetics, metabolism)
• RNA, Circular (genetics, metabolism)