Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis.

Abstract

Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases.

• Authors: Vinicius M Gadotti, Graciela Andonegui, Zizhen Zhang, Said M'Dahoma, Cristiane H Baggio, Lina Chen, Lilian Basso, Christophe Altier, Wallace K MacNaughton, Paul Kubes, Gerald W Zamponi
• Journal: iScience (iScience) Vol. 16 Pg. 12-21 (Jun 28 2019) ISSN: 2589-0042 [Electronic] United States
• PMID: 31146128 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.