Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets.

Abstract

Both diffusion-limited and perfusion-limited hypoxia are associated with tumor progression, metastasis, and the resistance to therapeutic modalities. A strategy that can efficiently overcome both types of hypoxia to enhance the efficacy of cancer treatment has not been reported yet. Here, it is shown that by using biomimetic ultrathin graphdiyne oxide (GDYO) nanosheets, both types of hypoxia can be simultaneously addressed toward an ideal photodynamic therapy (PDT). The GDYO nanosheets, which are oxidized and exfoliated from graphdiyne (GDY), are able to efficiently catalyze water oxidation to release O2 and generate singlet oxygen (1O2) using near-infrared irradiation. Meanwhile, GDYO nanosheets also exhibit excellent light-to-heat conversion performance with a photothermal conversion efficiency of 60.8%. Thus, after the GDYO nanosheets are coated with iRGD peptide-modified red blood membrane (i-RBM) to achieve tumor targeting, the biomimetic GDYO@i-RBM nanosheets can simultaneously enhance tumor reoxygenation and blood perfusion for PDT. This study provides new insights into utilizing novel water-splitting materials to relieve both diffusion- and perfusion-limited hypoxia for the development of a novel therapeutic platform.

• Authors: Wei Jiang, Zhen Zhang, Qin Wang, Jiaxiang Dou, Yangyang Zhao, Yinchu Ma, Huarong Liu, Hangxun Xu, Yucai Wang
• Journal: Nano letters (Nano Lett) Vol. 19 Issue 6 Pg. 4060-4067 (06 12 2019) ISSN: 1530-6992 [Electronic] United States
• PMID: 31136712 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oxides
• Carbon
• Oxygen

Topics

• Animals
• Biomimetic Materials (chemistry, therapeutic use)
• Carbon (chemistry, therapeutic use)
• Cell Line, Tumor
• Humans
• Mice, Inbred BALB C
• Nanostructures (chemistry, therapeutic use)
• Neoplasms (blood supply, metabolism, pathology, therapy)
• Oxides (chemistry, therapeutic use)
• Oxygen (metabolism)
• Photochemotherapy
• Tumor Hypoxia