Abstract |
Local recurrence is common among patients with advanced cancer who have undergone surgery. Here, we developed a new surgical treatment for cancer based on a nanoparticle that loaded a near-infrared dye (IR780 iodide) and perfluorooctyl bromide into liposomes (NP-IR780). In an orthotopic breast cancer mouse model, NP-IR780 was demonstrated to have excellent tumor-targeting ability due to the selective tumor accumulation of IR780 iodide and the enhanced permeation and retention effect of the nanoparticle. With the excellent targeting ability, concurrent computed tomography and photoacoustic imaging were achieved for preoperative planning. In particular, NP-IR780 could serve as a tumor indicator for near-infrared fluorescence image-guided precise resection of lesions during surgery. Importantly, residual tumors could be ablated through intraoperative photothermal therapy without obvious recurrence. This work provides a theranostic strategy that significantly improved the survival of mice through pre/intraoperative image-guided tumor resection and subsequent photothermal therapy of residual lesions.
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Authors | Jiao Song, Liang Zhang, Hengjing Yi, Ju Huang, Ni Zhang, Yixin Zhong, Lan Hao, Ke Yang, Zhigang Wang, Dong Wang, Zhu Yang |
Journal | Nanomedicine : nanotechnology, biology, and medicine
(Nanomedicine)
Vol. 20
Pg. 102020
(08 2019)
ISSN: 1549-9642 [Electronic] United States |
PMID | 31125675
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium
- Indoles
- Proliferating Cell Nuclear Antigen
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Topics |
- Animals
- Cell Line, Tumor
- Female
- Humans
- Hyperthermia, Induced
- Indoles
(chemistry)
- Mice, Inbred BALB C
- Nanoparticles
(chemistry, ultrastructure)
- Neoplasm Metastasis
- Neoplasm, Residual
(pathology, therapy)
- Phototherapy
- Proliferating Cell Nuclear Antigen
(metabolism)
- Spectroscopy, Near-Infrared
- Surgery, Computer-Assisted
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