Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain.

Abstract

Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate (Mag@CaP), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for Mag@CaP and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.

• Authors: Alessio Adamiano, Victoria M Wu, Francesca Carella, Gianrico Lamura, Fabio Canepa, Anna Tampieri, Michele Iafisco, Vuk Uskoković
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 14 Issue 10 Pg. 1267-1289 (05 2019) ISSN: 1748-6963 [Electronic] England
• PMID: 31124760 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Calcium Phosphates
• Magnetite Nanoparticles
• Durapatite
• Iron

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Bone Neoplasms (therapy)
• Brain Neoplasms (therapy)
• Calcium Phosphates (chemistry)
• Cell Line, Tumor
• Cell Survival
• Durapatite (chemistry)
• Fibroblasts (cytology)
• Humans
• Hyperthermia, Induced
• Iron (chemistry)
• Magnetic Fields
• Magnetite Nanoparticles (chemistry)
• Nanocomposites (chemistry)