BAM conditioning before autologous transplantation for lymphoma: a study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC).
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| Abstract |
High-dose chemotherapy before autologous transplantation is a therapeutic option as consolidation in primary or relapsed lymphoma. Even if BEAM conditioning is generally used, alternative conditioning regimens have been published. The purpose of this study was to assess the outcome of 177 adult patients with lymphoma whose conditioning treatment included a BAM (busulfan, aracytine, and melphalan) regimen. With a median follow-up of 17.4 months, 2-year estimates of overall survival and progression-free survival for the entire group were 87% and 70.5%, respectively. Mucositis was the main reported complications and infectious episodes were described in 80.2% of patients. According to multivariate analysis, high performance status and age at diagnosis were adverse factors for survival and increased the risk of disease relapse and death. Despite its limitations, this retrospective study suggests that BAM combination is a valid conditioning regimen in lymphoma patients, with an acceptable rate of toxicity.
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| Authors | Jérôme Cornillon, Elisabeth Daguenet, Jacques-Olivier Bay, Adrien Chauchet, Gilles Salles, Nathalie Contentin, Emmanuelle Nicolas-Virelizier, Mélanie Mercier, Nicolas Vallet, Magda Alexis, Marie-Lorraine Chrétien, Thomas Cluzeau, Anne Huynh, Chantal Himberlin, Véronique Dorvaux, Sandy Amorim, Caroline Lejeune, Régis Peffault de Latour, Emmanuel Gyan |
| Journal | Annals of hematology (Ann Hematol) Vol. 98 Issue 8 Pg. 1973-1980 (Aug 2019) ISSN: 1432-0584 [Electronic] Germany |
| PMID | 31111177 (Publication Type: Journal Article) |
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