Association of serum podocalyxin levels with peripheral arterial disease in patients with type 2 diabetes.

Abstract

OBJECTIVE:

Renal podocalyxin is a marker for kidney diseases. Previous studies have shown the expression of serum podocalyxin (s-Podxl) in the endothelial cells of blood vessels. We aimed to investigate the association between s-podxl levels and peripheral arterial disease (PAD) in subjects with type 2 diabetes (T2DM).

SUBJECTS AND METHODS:

Serum Podxl levels were analyzed in 69 subjects with normal glucose tolerance and PAD (NGT-PAD), 120 subjects with T2DM and PAD (D-PAD) and 36 subjects with T2DM without PAD (D-NPAD).

RESULTS:

In D-PAD Patients, s-Podxl was significantly higher (17.67 ± 20.7 ng/mL) than in D-NPAD subjects (9.97 ± 5.34 ng/mL; P < 0.001). Subjects with NGT-PAD had significantly higher s-Podxl levels (15.34 ± 18.21 ng/mL), than D-NPAD patients (P < 0.001). Subjects with D-PAD and medial calcific sclerosis (MCS) had significantly higher s-Podxl levels compared to the same group but without MCS (P < 0.02). In D-PAD patients, MCS (P = 0.003) and glycosylated hemoglobin (P < 0.001) were the two variables that had the strongest prediction for s-Podxl as revealed by regression analysis. Multivariate regression showed that an increase of one standard deviation in s-Podxl was associated with an odds ratio of 3.4 (95% confidence interval = 2.2-4.6, P < 0.001) for the prevalence of PAD.

CONCLUSIONS:

This is the first study showing an association between s-Podxl and PAD in patients with T2DM. S-Podxl was higher in D-PAD patients than in D-NPAD subjects. In NGT-PAD patients, s-Podxl was also higher than in D-NPAD patients. In patients with D-PAD, s-Podxl was positively associated with MCS.

• Authors: Hazem M El-Ashmawy, Fayrouz O Selim, Thoraya A M Hosny, Hosam N Almassry
• Journal: Journal of diabetes and its complications (J Diabetes Complications) Vol. 33 Issue 7 Pg. 495-499 (07 2019) ISSN: 1873-460X [Electronic] United States
• PMID: 31097305 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Glycated Hemoglobin A
• Sialoglycoproteins
• podocalyxin

Topics

• Aged
• Ankle Brachial Index
• Atherosclerosis (blood, complications, epidemiology)
• Biomarkers (blood)
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, complications, epidemiology)
• Diabetic Angiopathies (blood, epidemiology)
• Egypt (epidemiology)
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Male
• Middle Aged
• Peripheral Arterial Disease (blood, complications, epidemiology)
• Prevalence
• Risk Factors
• Sialoglycoproteins (blood)