Abstract | INTRODUCTION:
Radiation pneumonitis is a major dose-limiting complication in thoracic radiation therapy (RT) and presents clinically in the first few months after RT. We evaluated the feasibility of quantifying pulmonary parenchymal glycolysis (PG) as a surrogate of global lung inflammation and radiation-induced pulmonary toxicity using a novel semiautomatic lung segmentation technique in non-small-cell lung cancer (NSCLC) patients and compared PG in patients treated with photon or proton RT. PATIENTS AND METHODS: We evaluated 18 consecutive locally advanced NSCLC patients who underwent pretreatment and post-treatment F-FDG PET/CT treated with definitive (median: 66.6 Gy; 1.8 Gy fractions) photon or proton RT between 2010 and 2014. Lung volume segmentation was conducted using 3D Slicer by performing simple thresholding. Pulmonary PG was calculated by summing F-FDG uptake in the whole lung. RESULTS: In nine patients treated with photon RT, significant increases in PG in both ipsilateral (mean difference: 1400±510; P=0.02) and contralateral (mean difference: 1200±450; P=0.03) lungs were noted. In nine patients treated with proton therapy, no increase in pulmonary PG was observed in either the ipsilateral (P=0.30) or contralateral lung (P=0.98). CONCLUSION:
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Authors | Stephanie R Rice, Babak Saboury, Sina Houshmand, Ali Salavati, Anusha Kalbasi, Chelain R Goodman, Thomas J Werner, Zeljko Vujaskovic, Charles B Simone 2nd, Abass Alavi |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 40
Issue 6
Pg. 618-625
(Jun 2019)
ISSN: 1473-5628 [Electronic] England |
PMID | 31095527
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Carcinoma, Non-Small-Cell Lung
(pathology, therapy)
- Chemoradiotherapy
(adverse effects)
- Female
- Fluorodeoxyglucose F18
- Humans
- Lung Neoplasms
(pathology, therapy)
- Male
- Middle Aged
- Photons
(adverse effects, therapeutic use)
- Pneumonia
(diagnostic imaging, etiology)
- Positron Emission Tomography Computed Tomography
- Proton Therapy
(adverse effects)
- Radiation Injuries
(diagnostic imaging, etiology)
- Retrospective Studies
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