Initial Experience With Radium-223 Chloride Treatment at the Kanazawa University Hospital.

Abstract

BACKGROUND/AIM:

To evaluate our initial experience with radium-223 chloride (Ra-223).

MATERIALS AND METHODS:

A total of 26 castration-resistant prostate cancer (CRPC) patients with bone metastases, treated with Ra-223 at our hospital were evaluated. This study aimed to observe adverse events (AEs) and changes in serum markers, and Bone Scan Index (BSI). Additionally, the relationship between these values and OS was investigated.

RESULTS:

The observed AEs mainly included fatigue and nausea. Alkaline phosphatase (ALP) and bone-type alkaline phosphatase (BAP) levels decreased following the treatment; however, those of PSA and 1-CTP tended to increase, regardless of Ra-223 administration. Overall survival (OS) was significantly improved in cases with a baseline BSI value of <2 compared with those with a baseline BSI value of ≥2. Moreover, the decrease in BSI after administration of Ra-223 was an independent factor, significantly prolonging OS.

CONCLUSION:

ALP and BAP levels and BSI values are suitable evaluation markers during treatment with Ra-223. Also, baseline BSI values and the decrease in BSI following treatment are independent factors predicting OS.

• Authors: Kazufumi Nakashima, Tomoyuki Makino, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Masashi Iijima, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Shinro Matsuo, Atsushi Mizokami
• Journal: Anticancer research (Anticancer Res) Vol. 39 Issue 5 Pg. 2607-2614 (May 2019) ISSN: 1791-7530 [Electronic] Greece
• PMID: 31092459 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Radium-223
• Alkaline Phosphatase
• Prostate-Specific Antigen
• Radium

Topics

• Aged
• Alkaline Phosphatase (blood)
• Bone Neoplasms (blood, pathology, radiotherapy, secondary)
• Bone and Bones (diagnostic imaging, radiation effects)
• Disease-Free Survival
• Drug-Related Side Effects and Adverse Reactions (blood, classification, pathology)
• Humans
• Male
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms, Castration-Resistant (blood, pathology, radiotherapy)
• Radium (administration & dosage)
• Treatment Outcome