Serum Phosphate and the Risk of New-Onset Hyperuricemia in Hypertensive Patients.

Abstract

The relationship of serum phosphate and new-onset hyperuricemia remains uncertain. We aimed to evaluate the relationship of serum phosphate with the risk of new-onset hyperuricemia, and to examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric Acid substudy of the CSPPT (China Stroke Primary Prevention Trial). A total of 10 612 participants with normal uric acid levels (<357 μmol/L [6 mg/dL]) at baseline were included in the current study. The primary outcome was new-onset hyperuricemia, which was defined as a uric acid concentration ≥417 μmol/L (7 mg/dL) in men or ≥357 μmol/L (6 mg/dL) in women. During a median follow-up of 4.4 years, 1663 (15.7%) participants developed new-onset hyperuricemia. Overall, there was a significant inverse association between serum phosphate and the risk of new-onset hyperuricemia (per SD increment; odds ratio, 0.71; 95% CI, 0.66-0.76). When serum phosphate was assessed as quartiles, a significantly lower risk of new-onset hyperuricemia was found in participants in quartile 4 (≥1.4 mmol/L; odds ratio, 0.48; 95% CI, 0.40-0.57) compared with those in quartile 1 (<1.2 mmol/L). Similar results were found in males and females. In summary, there was an inverse association between serum phosphate and the risk of new-onset hyperuricemia in hypertensive adults.

• Authors: Jingjing Cao, Jingping Zhang, Qinqin Li, Chongfei Jiang, Yun Song, Chengzhang Liu, Lishun Liu, Binyan Wang, Jianping Li, Yan Zhang, Yimin Cui, Yong Huo, Xiaobin Wang, Genfu Tang, Xiping Xu, Xianhui Qin
• Journal: Hypertension (Dallas, Tex. : 1979) (Hypertension) Vol. 74 Issue 1 Pg. 102-110 (07 2019) ISSN: 1524-4563 [Electronic] United States
• PMID: 31079533 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Phosphates
• Uric Acid

Topics

• Age Factors
• Aged
• Biomarkers (blood)
• China
• Comorbidity
• Confidence Intervals
• Double-Blind Method
• Female
• Humans
• Hypertension (diagnosis, epidemiology)
• Hyperuricemia (blood, epidemiology)
• Incidence
• Male
• Middle Aged
• Odds Ratio
• Phosphates (blood)
• Prognosis
• Retrospective Studies
• Risk Assessment
• Severity of Illness Index
• Sex Factors
• Uric Acid (blood)