Abstract | OBJECTIVES: Patients with various inflammatory rheumatic diseases (IRDs) have increased risk of atherothrombotic disease. Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear. We aimed to examine if serum Lp(a) levels differed between CAD patients with and without accompanying IRD. DESIGN: A cross-sectional observational, patient-based cohort study. SETTING: PARTICIPANTS: 67 CAD patients with IRD (CAD/IRD) and 52 CAD patients without IRD (CAD/non-IRD). All patients were Caucasians, aged >18 years, without any clinically significant infection or malignancy. METHODS: Lp(a) levels in serum were analysed by particle enhanced immunoturbidimetric assay, and Lp(a) levels were related to clinical and biochemical characteristics of the patient population. RESULTS: We found no differences in serum levels of Lp(a) between CAD patients with and without IRD. In general, we found that Lp(a) correlated poorly with clinical and biochemical parameters including C reactive protein with the same pattern in the CAD/non-IRD and CAD/IRD groups. CONCLUSIONS: Our data do not support a link between inflammation and Lp(a) levels in CAD and in general Lp(a) levels were not correlated with other risk factors for cardiovascular disease.
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Authors | Sverre Holm, Ingvild Oma, Tor-Arne Hagve, Kjell Saatvedt, Frank Brosstad, Knut Mikkelsen, Hans Rydningen, Ivar Risnes, Sven Martin Almdahl, Thor Ueland, Pål Aukrust, Bente Halvorsen, Ivana Hollan |
Journal | BMJ open
(BMJ Open)
Vol. 9
Issue 5
Pg. e030651
(05 10 2019)
ISSN: 2044-6055 [Electronic] England |
PMID | 31079089
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
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Topics |
- Adult
- Aged
- Cohort Studies
- Coronary Artery Disease
(blood, complications)
- Cross-Sectional Studies
- Female
- Humans
- Inflammation
(blood, complications)
- Lipoprotein(a)
(blood)
- Male
- Middle Aged
- Rheumatic Diseases
(blood, complications)
- Risk Factors
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