Abstract | BACKGROUND: METHODS: Adult male TREK-1-/- mice and WT mice were subjected to a collagenase-induced ICH model. Immunostaining, western blot, and enzyme-linked immunosorbent assay were used to assess inflammatory infiltration and neuronal death. Blood-brain barrier compromise was assessed using electron microscopy and Evans Blue dye injection on days 1 and 3 after intracerebral hemorrhage. Magnetic resonance imaging and behavioral assessments were conducted to evaluate the neurologic damage and recovery after intracerebral hemorrhage. RESULTS: CONCLUSIONS:
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Authors | Yongkang Fang, Yeye Tian, Qibao Huang, Yue Wan, Li Xu, Wei Wang, Dengji Pan, Suiqiang Zhu, Minjie Xie |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 16
Issue 1
Pg. 96
(May 09 2019)
ISSN: 1742-2094 [Electronic] England |
PMID | 31072336
(Publication Type: Journal Article)
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Chemical References |
- Potassium Channels, Tandem Pore Domain
- potassium channel protein TREK-1
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Topics |
- Animals
- Blood-Brain Barrier
(metabolism, pathology)
- Cerebral Hemorrhage
(metabolism, pathology)
- Inflammation
(metabolism, pathology)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Potassium Channels, Tandem Pore Domain
(metabolism)
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