[Enteropathy-associated T-cell lymphoma coexisting with composite lymphoma composed of DLBCL and PTCL].

Abstract

The patient was a 73-year-old man diagnosed with low-grade B-cell lymphoma not otherwise specified based on a biopsy of the enlarged cervical lymph nodes. He remained untreated and was monitored during follow-up visits only. Progressive anemia developed after 5 years. Enteroscopy revealed stricture and ulcerative lesions involving the entire circumference of the middle section of the small intestine. Based on the biopsy results, he was diagnosed with enteropathy-associated T-cell lymphoma (EATL). Biopsy of an enlarged axillary lymph node simultaneously revealed Epstein-Barr virus-negative diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma not otherwise specified (PTCL, NOS) as well as rearrangement of immunoglobulin heavy-chain and T-cell receptor beta and gamma chain genes. These findings suggested that the axillary lymph node contained composite lymphoma comprising DLBCL and PTCL and that EATL represented a discordant lymphoma. The present case emphasizes the importance of re-biopsy and genetic analysis following an atypical clinical course.

• Authors: Daisuke Imanishi, Tomoko Hata, Yoshitaka Imaizumi, Daisuke Niino, Koichi Ohshima, Yasushi Miyazaki
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 60 Issue 3 Pg. 197-202 ( 2019) ISSN: 0485-1439 [Print] Japan
• PMID: 31068515 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Composite Lymphoma (complications)
• Enteropathy-Associated T-Cell Lymphoma (complications)
• Herpesvirus 4, Human
• Humans
• Lymph Nodes (pathology)
• Lymphoma, Large B-Cell, Diffuse (complications)
• Lymphoma, T-Cell, Peripheral (complications)
• Male