Abstract | BACKGROUND: MAIN BODY: A positive overall survival outcome was achieved only in PD-L1+ TNBC patients, suggesting a need to enrich the patient population more likely to benefit from an immunotherapeutic approach. Moreover, it remains unknown whether single-agent immunotherapy might be a good option for some patients. In this context, the discovery and implementation of novel and appropriate biomarkers are required. Focusing on the early onset of TNBC, neoadjuvant trials could represent excellent in vivo platforms to test immunotherapy agents and their potential combinations, allowing the performance of translational studies for biomarker implementation and improved patient selection. CONCLUSION: The aim of our review is to present recent advances in TNBC treatment and to discuss open issues in order to better define potential future directions for immunotherapy in TNBC.
|
Authors | Antonio Marra, Giulia Viale, Giuseppe Curigliano |
Journal | BMC medicine
(BMC Med)
Vol. 17
Issue 1
Pg. 90
(05 09 2019)
ISSN: 1741-7015 [Electronic] England |
PMID | 31068190
(Publication Type: Journal Article, Review)
|
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- B7-H1 Antigen
- CD274 protein, human
- Immunologic Factors
- atezolizumab
|
Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
- B7-H1 Antigen
(immunology)
- Female
- Humans
- Immunologic Factors
(therapeutic use)
- Immunotherapy
(methods, trends)
- Medical Oncology
(methods, trends)
- Neoadjuvant Therapy
- Triple Negative Breast Neoplasms
(drug therapy, therapy)
|