4,5-Diaryl 3(2H)Furanones: Anti-Inflammatory Activity and Influence on Cancer Growth.

Abstract

Apart from their anti-inflammatory action, COX inhibitors have gathered the interest of many scientists due to their potential use for the treatment and prevention of cancer. It has been shown that cyclooxygenase inhibitors restrict cancer cell growth and are able to interact with known antitumor drugs, enhancing their in vitro and in vivo cytotoxicity. The permutation of hydrophilic and hydrophobic aryl groups in COX inhibitors leads to cardinal changes in the biological activity of the compounds. In the present study, thirteen heterocyclic coxib-like 4,5-diarylfuran-3(2H)-ones and their annelated derivatives-phenanthro[9,10-b]furan-3-ones-were synthesized and studied for anti-inflammatory and COX-1/2 inhibitory action and for their cytotoxic activity on the breast cancer (MCF-7) and squamous cell carcinoma (HSC-3) cell lines. The F-derivative of the -SOMe substituted furan-3(2H)-ones exhibited the best activity (COX-1 IC50 = 2.8 μM, anti-inflammatory activity (by carrageenan paw edema model) of 54% (dose 0.01 mmol/kg), and MCF-7 and HSC-3 cytotoxicity with IC50 values of 10 μM and 7.5 μM, respectively). A cytotoxic effect related to the COX-1 inhibitory action was observed and a synergistic effect with the anti-neoplastic drugs gefitinib and 5-fluorouracil was found. A phenanthrene derivative exhibited the best synergistic effect with gefitinib.

• Authors: Dmitrii Semenok, Jury Medvedev, Lefki-P Giassafaki, Iason Lavdas, Ioannis S Vizirianakis, Phaedra Eleftheriou, Antonis Gavalas, Anthi Petrou, Athina Geronikaki
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 24 Issue 9 (May 06 2019) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 31064095 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Cyclooxygenase 2 Inhibitors
• Furans
• Fluorine
• Carrageenan
• Cyclooxygenase 2

Topics

• Amino Acid Sequence
• Amino Acids (chemistry)
• Anti-Inflammatory Agents, Non-Steroidal (chemistry, pharmacology)
• Antineoplastic Agents (chemistry, pharmacology)
• Carrageenan (metabolism)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Cyclooxygenase 2 (metabolism)
• Cyclooxygenase 2 Inhibitors (chemistry, pharmacology)
• Drug Design
• Edema (metabolism)
• Fluorine (chemistry)
• Furans (chemistry, pharmacology)
• Humans
• Molecular Docking Simulation
• Molecular Structure
• Protein Binding
• Structure-Activity Relationship