Score of the preoperative absolute number of lymphocytes, monocytes, and neutrophils as a prognostic indicator for patients with gastric cancer.

Abstract

PURPOSE:

The association between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of gastric cancer (GC) patients has not been investigated widely.

METHODS:

We enrolled 445 patients who underwent surgery for GC between January, 2005 and April, 2013 to analyze the correlations among NC, LC, and MC and their prognoses.

RESULTS:

Based on cut-off values calculated by ROC analysis, patients were sub grouped as having: NC ≥ 4477 (NCHigh), NC < 4477 (NCLow); and as LC ≥ 1447 (LCHigh), LC < 1447 (LCLow); and as MC ≥ 658.5 (MCHigh), MC < 658.5 (MCLow). Each group was assigned as follows; NCHigh group = 1, NCLow group = 0, LCHigh group = 0, LCLow group = 1, MCHigh group = 1, MCLow group = 0, and the sum of each score was defined as the lymphocyte-monocyte-neutrophil score (LMN score). The overall 5-year survival rates were 89%, 74%, 57.8%, and 53.3% for LMN scores of 0, 1, 2, and 3, respectively (P = 0.0004). Multivariate analysis indicated that the LMN score was an independent prognostic indicator.

CONCLUSIONS:

The combination of preoperative NC, LC, and MC appears to be a useful indicator of GC prognosis.

• Authors: Hiroaki Saito, Shota Shimizu, Yusuke Kono, Yuki Murakami, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Keigo Ashida, Yoshiyuki Fujiwara
• Journal: Surgery today (Surg Today) Vol. 49 Issue 10 Pg. 850-858 (Oct 2019) ISSN: 1436-2813 [Electronic] Japan
• PMID: 31062094 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Aged
• Biomarkers, Tumor (blood)
• Female
• Humans
• Leukocyte Count
• Lymphocyte Count
• Male
• Monocytes
• Multivariate Analysis
• Neutrophils
• Preoperative Period
• Prognosis
• Stomach Neoplasms (blood, diagnosis, mortality)
• Survival Rate