Abstract | STUDY OBJECTIVES: METHODS: A retrospective database was created for children with RLS/PLMD who were treated with iron therapy. These participants were followed for at least 1 year at Cincinnati Children's Hospital Medical Center. All participants had ferritin level testing and were treated with iron therapy. In addition, all participants underwent polysomnography before starting iron therapy for RLS/PLMD except for one participant who was already on iron but required a higher dose. Most participants underwent polysomnography after iron therapy. RESULTS: A total of 226 participants were identified with the diagnosis of RLS/PLMD. Of these, 50 had parasomnias and 30 of them were treated with iron therapy. Of the 30 participants, RLS symptoms improved in 15 participants (50%) and resolution of parasomnias was noted in 12 participants (40%) participants after iron therapy. Repeat polysomnography after iron therapy was performed in 21 participants (70%). After iron therapy, there was a significant decrease in periodic limb movement index (17.2 ± 8.8 [before] versus 6.7 ± 7.3 [after] events/h, P < .001). In addition, there were significant decreases in PLMS (24.52 ± 9.42 [before] versus 7.50 ± 7.18 [after] events/h, P < .0001), PLMS-related arousals (4.71 ± 1.81 [before] versus 1.35 ± 1.43 [after] events/h, P < .0001), and total arousals (11.65 ± 5.49 [before] versus 8.94 ± 3.65 [after] events/h, P < .01) after iron therapy. CONCLUSIONS:
Parasomnias are common in our cohort of children with RLS/PLMD. Iron therapy was associated with a significant improvement in periodic limb movement index, RLS symptoms, and resolution of a significant proportion of NREM sleep parasomnias, suggesting that RLS/PLMD may precipitate NREM sleep parasomnia.
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Authors | Neepa Gurbani, Thomas J Dye, Kyle Dougherty, Sejal Jain, Paul S Horn, Narong Simakajornboon |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 15
Issue 5
Pg. 743-748
(05 15 2019)
ISSN: 1550-9397 [Electronic] United States |
PMID | 31053208
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 American Academy of Sleep Medicine. |
Chemical References |
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Topics |
- Child
- Cohort Studies
- Female
- Humans
- Iron
(therapeutic use)
- Male
- Nocturnal Myoclonus Syndrome
(complications, drug therapy, physiopathology)
- Parasomnias
(complications, drug therapy, physiopathology)
- Polysomnography
(methods)
- Restless Legs Syndrome
(complications, drug therapy, physiopathology)
- Retrospective Studies
- Treatment Outcome
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