Abstract | OBJECTIVES: DESIGN: Prospective cohort study. METHODS: Data collected from HIV-negative FSWs from 1993 to 2017 were analyzed. Cox proportional hazards models were used to assess the relationship between HIV seroconversion and use of DMPA, OCPs, or hormonal contraceptive implants ( Norplant, Jadelle). RESULTS: A total of 1985 women contributed 7127 person-years of follow-up; 307 women seroconverted to HIV (4.32/100 person-years). DMPA was significantly associated with elevated risk of HIV seroconversion in women with [aHR 1.56, 95% confidence interval (CI) 1.08-2.25; P = 0.02] and without (aHR 2.08, 95% CI 1.46-2.97; P < 0.001) bacterial vaginosis (interaction P = 0.4). Similarly, OCP use was associated with increased HIV risk both in the presence (aHR 1.50, 95% CI 0.94-2.39; P = 0.09) and absence (aHR 1.61, 95% CI 0.99-2.64; P = 0.06) of bacterial vaginosis (interaction P = 0.9), though neither stratum reached statistical significance. Implants were not associated with HIV seroconversion overall (aHR 0.99, 95% CI 0.40-2.45; P = 0.9), or in women with (aHR 0.65, 95% CI 0.16-2.72; P = 0.6) and without (aHR 1.39, 95% CI 0.43-4.46; P = 0.6) bacterial vaginosis (interaction P = 0.5). CONCLUSION:
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Authors | Michelle C Sabo, Barbra A Richardson, Ludo Lavreys, Harold L Martin Jr, Walter Jaoko, Kishorchandra Mandaliya, Jared M Baeten, Julie Overbaugh, R Scott McClelland |
Journal | AIDS (London, England)
(AIDS)
Vol. 33
Issue 7
Pg. 1225-1230
(06 01 2019)
ISSN: 1473-5571 [Electronic] England |
PMID | 31048629
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contraceptives, Oral, Hormonal
- Medroxyprogesterone Acetate
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Topics |
- Adult
- Contraception
(methods)
- Contraceptives, Oral, Hormonal
(administration & dosage, adverse effects)
- Female
- HIV Seropositivity
(epidemiology, transmission)
- Humans
- Kenya
(epidemiology)
- Medroxyprogesterone Acetate
(administration & dosage, adverse effects)
- Proportional Hazards Models
- Prospective Studies
- Risk Assessment
- Risk Factors
- Sex Workers
(statistics & numerical data)
- Vaginosis, Bacterial
(epidemiology)
- Young Adult
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