circMAN1A2 could serve as a novel serum biomarker for malignant tumors.

Abstract

Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real-time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.

• Authors: Chun-Mei Fan, Jin-Peng Wang, Yan-Yan Tang, Jin Zhao, Shu-Yi He, Fang Xiong, Can Guo, Bo Xiang, Ming Zhou, Xiao-Ling Li, Yong Li, Gui-Yuan Li, Wei Xiong, Zhao-Yang Zeng
• Journal: Cancer science (Cancer Sci) Vol. 110 Issue 7 Pg. 2180-2188 (Jul 2019) ISSN: 1349-7006 [Electronic] England
• PMID: 31046163 (Publication Type: Journal Article)
• Copyright: © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• Biomarkers, Tumor
• RNA, Circular
• RNA

Topics

• Biomarkers, Tumor (blood, genetics)
• Early Detection of Cancer
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (blood, diagnosis, genetics)
• Male
• Mouth Neoplasms (blood, diagnosis, genetics)
• Nasopharyngeal Carcinoma (blood, diagnosis, genetics)
• Neoplasms (blood, diagnosis, genetics)
• Ovarian Neoplasms (blood, diagnosis, genetics)
• RNA (genetics)
• RNA, Circular
• ROC Curve
• Real-Time Polymerase Chain Reaction
• Thyroid Neoplasms (blood, diagnosis, genetics)
• Up-Regulation
• Exome Sequencing