Double plastic stenting for inoperable malignant biliary stricture among cirrhotic patients as a possible cost-effective treatment: a pilot study.

Abstract

BACKGROUND AND STUDY AIM:

Endoscopic retrograde cholangiopancreatography (ERCP) has evolved as the main therapeutic intervention for hepatobiliary disorders. Palliative stenting for inoperable cases is associated with better morbidity and mortality than surgery. This work aimed at assessing the effect of insertion of two plastic stents in inoperable malignant biliary stricture among cirrhotic patients regarding stent patency, quality of life (QOL), and cost.

PATIENTS AND METHODS:

This multicenter study included 72 cirrhotic patients presented for ERCP with an inoperable malignant biliary stricture. All patients underwent ERCP after preoperative optimization with sphincterotomy, balloon dilatation, and insertion of two plastic stents of 10 Fr. Evaluation included stent patency at 6 months, effect on the QOL using EORTC QLQ-C30 (version 3), adverse events, and the cost.

RESULTS:

Patients included 67% of males and had an age range of 48-88 years (mean: 70 years). In all, 92% of stents were patent at 6 months. Significant improvement in serum total bilirubin and all items of QOL questionnaire at 6 months after the procedure was reported. Cholangitis and pancreatitis were reported in 25 and 8% of cases, respectively. The cost of insertion of two plastic stents and the daily cost of the procedure regarding the effect on QOL were low.

CONCLUSION:

Double plastic stenting of the common bile duct seems effective at 6 months of follow-up among cirrhotic patients with inoperable malignant biliary obstruction. Furthermore, it seems also valuable in improving laboratory findings and QOL among those patients with an acceptable cost.

• Authors: Mohamed I Radwan, Mohamed H Emara, Mariam S Zaghloul, Abdallah M S Zaghloul
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 31 Issue 8 Pg. 1057-1063 (Aug 2019) ISSN: 1473-5687 [Electronic] England
• PMID: 31045612 (Publication Type: Journal Article, Multicenter Study)

Topics

• Aged
• Aged, 80 and over
• Cholangiopancreatography, Endoscopic Retrograde (economics, methods)
• Cholestasis (diagnosis, etiology, surgery)
• Common Bile Duct (diagnostic imaging, surgery)
• Cost-Benefit Analysis
• Female
• Humans
• Liver Cirrhosis (complications, diagnosis)
• Liver Neoplasms (complications, diagnosis)
• Male
• Middle Aged
• Pilot Projects
• Prosthesis Design
• Quality of Life
• Stents
• Treatment Outcome