Comparison of different methods for the extraction of cannabinoids from cannabis.

Abstract

Cannabis oils, namely concentrated cannabis extracts, are getting plenty of attention because of their therapeutic potential for treatment of patients with cancer, HIV, multiple sclerosis and several other pathologies. Here we propose the use of ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) as alternative methods to the current protocols followed by pharmacists, the only authorized to manipulate standardized Cannabis. A third method, consisting of the use of Tween 20 as surfactant, was considered. Our best extraction methodology for commercial hemp extraction was applied to medicinal cannabis. Here we report the results obtained for 'Eletta campana', 'Carmagnola selezionata', Bediol®, FM2® and Bedrocan®.

• Authors: Daniela De Vita, Valentina Noemi Madia, Valeria Tudino, Francesco Saccoliti, Alessandro De Leo, Antonella Messore, Patrizia Roscilli, Alfonso Botto, Ivano Pindinello, Gianluigi Santilli, Luigi Scipione, Roberta Costi, Roberto Di Santo
• Journal: Natural product research (Nat Prod Res) Vol. 34 Issue 20 Pg. 2952-2958 (Oct 2020) ISSN: 1478-6427 [Electronic] England
• PMID: 31035854 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cannabinoids
• Plant Extracts
• Polysorbates
• Surface-Active Agents

Topics

• Cannabinoids (chemistry, isolation & purification)
• Cannabis (chemistry)
• Chemical Fractionation (methods)
• Microwaves
• Molecular Structure
• Plant Extracts (chemistry)
• Polysorbates (chemistry)
• Surface-Active Agents (chemistry)
• Ultrasonics