Clinical correlates of repetitive speech disorders in Parkinson's disease.

Abstract

OBJECTIVES:

This study aimed to explore clinical correlates of repetitive speech disorders in patients with Parkinson's disease (PD).

METHODS:

This study investigated speech function (Assessment of Motor Speech for Dysarthria and Stuttering Severity Instrument-3), motor function (Unified Parkinson's Disease Rating Scale III [UPDRS-III] and UPDRS-IV), cognitive function (Mini-Mental State Examination [MMSE], Montreal Cognitive Assessment [MoCA], Stroop color-word test, verbal fluency, digit span tests, and line orientation), and activities of daily living of 113 PD patients. Comparison between groups (independent t-tests, Mann-Whitney U tests, or χ2 test) and linear regression analyses were performed to determine clinical correlates of repetitive speech disorders.

RESULTS:

Totally, 65 patients (57.5%) had repetitive speech disorders. Patients with repetitive speech disorders had significantly worse UPDRS-III (P = .049), MoCA (P = .030), and speech function and higher levodopa equivalent daily dose (LEDD; P = .031) than those without repetitive speech disorders. Males were significantly predominant in patients with repetitive speech disorders (64.6%) compared to those without repetitive speech disorders (18.7%; P < .001). The univariate and subsequent multiple linear regression analyses revealed that the severity of repetitive speech disorders significantly correlated with gender (P < .001), MoCA (P = .006), and speech variables (abnormal rate, P = .007; imprecise consonants, P = .043), independent from disease duration, UPDRS III, and LEDD.

CONCLUSIONS:

PD patients with repetitive speech disorders had worse motor, cognitive, and speech functions than those without repetitive speech disorders. The most influential factor for repetitive speech disorders might be male gender.

• Authors: Takashi Tsuboi, Hirohisa Watanabe, Yasuhiro Tanaka, Reiko Ohdake, Maki Sato, Makoto Hattori, Kazuya Kawabata, Kazuhiro Hara, Daisuke Nakatsubo, Satoshi Maesawa, Yasukazu Kajita, Masahisa Katsuno, Gen Sobue
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 401 Pg. 67-71 (Jun 15 2019) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 31029883 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Antiparkinson Agents
• Levodopa

Topics

• Activities of Daily Living
• Aged
• Antiparkinson Agents (administration & dosage, therapeutic use)
• Cognition
• Dyskinesias (etiology, physiopathology)
• Female
• Humans
• Levodopa (administration & dosage, therapeutic use)
• Male
• Memory
• Mental Status and Dementia Tests
• Middle Aged
• Parkinson Disease (complications, psychology)
• Sex Factors
• Speech Disorders (etiology, psychology)
• Speech Production Measurement
• Stroop Test
• Verbal Behavior