Therapeutic apheresis in neurological, nephrological and gastrointestinal diseases.

Abstract

Therapeutic plasma exchange (TPE) is a process in which plasma containing antibodies, immune complexes, inflammatory moderators, paraproteins and other toxins which are believed to be the cause of disease is removed from a patient. TPE is the first-line treatment (category I, level 1A) in all forms of Acute inflammatory demyelinating polyradiculoneuropathy disease (axonal, demyelinating and miller-fisher variant) as well as in acute myasthenic crisis, chronic inflammatory demyelinating polyradiculoneuropathy and Paraproteinemic neuropathies (category I, level 1B). Moreover, TPE in kidney diseases, for instance: desensitization in renal transplantation(ABO compatible) (living donor)and desensitization in deceased donor, desensitization in renal transplantation(ABO incompatible) (living donor), thrombotic microangiopathy complement Mediated (Factor H autoantibodies), Focal segmental glomerulosclerosis(recurrent in transplanted kidney), ANCA-associated rapidly progressive glomerulonephritis(Dialysis dependence, DAH), Anti-Glomerular basement membrane disease Goodpasture's syndrome)(DAH,Dialysis-independence,) has been utilized as an initial treatment. (category I) TPE has been used as the key therapeutic modality to reduce anti-A or anti-B antibody titers in the liver peri-transplant period with the goal of preventing rejection and facilitating graft survival. Also, plasma exchange is the first-line therapy in Wilson's disease (category I, level1C).

• Authors: Azita Chegini, Sanaz Ahmadi Karvigh, Maryam Rahbar, AliReza Sharifi Rayeni
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 58 Issue 3 Pg. 266-272 (Jun 2019) ISSN: 1473-0502 [Print] England
• PMID: 31029610 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019. Published by Elsevier Ltd.

Chemical References

• ABO Blood-Group System

Topics

• ABO Blood-Group System
• Blood Component Removal
• Gastrointestinal Diseases (therapy)
• Humans
• Kidney Diseases (therapy)
• Kidney Transplantation
• Liver Diseases (therapy)
• Liver Transplantation
• Living Donors
• Nervous System Diseases (therapy)
• Plasma Exchange