A novel microRNA signature predicts vascular invasion in hepatocellular carcinoma.

Abstract

Vascular invasion (VI) in hepatocellular carcinoma (HCC) is an important clinical parameter to predict survival. In this study, we collected microRNA (miRNA) expression data from HCC patients using The Cancer Genome Atlas database and identified a novel miRNA signature associated with VI. First, we categorized HCC patients into groups with or without VI (VI+ and VI-). We identified three miRNAs (miRNA-210, miRNA-10b, and miRNA-9-1) that were associated with VI according to a Kaplan-Meier analysis. This three-miRNA signature exhibited good predictive ability for VI in patients with HCC according to a receiver operating characteristic curve analysis at 1, 3, and 5 years. Patients with HCC with a high risk score exhibited a trend toward worse outcomes as determined by multivariable Cox regression and stratified analyses. This three-miRNA signature provides an accurate prediction of VI and can be used as an independent prognostic indicator for predicting VI in HCC patients.

• Authors: Bing Han, Yujia Zheng, Le Wang, Haixu Wang, Jiaxin Du, Fanglei Ye, Tongwen Sun, Lianfeng Zhang
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 11 Pg. 20859-20868 (11 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30997686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• MicroRNAs

Topics

• Animals
• Carcinoma, Hepatocellular (blood supply, genetics)
• Cell Proliferation (genetics)
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Hep G2 Cells
• Humans
• Kaplan-Meier Estimate
• Liver Neoplasms (blood supply, genetics)
• Mice, Nude
• MicroRNAs (genetics, metabolism)
• Neovascularization, Pathologic (genetics)
• Prognosis
• Reproducibility of Results
• Risk Factors
• Survival Analysis