Abstract | BACKGROUND: Breast adenomyoepithelioma ( AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology. METHODS: We queried health records containing " adenomyoepithelioma" between 2000 and 2018. Histology was confirmed with centralized review and classified into benign, atypical, and malignant. Clinical characteristics, demographics, treatment, and oncologic outcomes were compared. RESULTS: Our query yielded 24 patients with adenomyoethelioma. Histologic diagnosis was confirmed in 12 (benign n = 6, atypical n = 3, malignant n = 3). Excision (n = 11) was the usual initial treatment, with margin status available in 10 patients. Mean follow up was 44 months (range 1-138 months) with no local recurrence observed. Two patients with benign AME presented with concurrent contralateral breast cancer, and one with malignant AME died of metastatic AME. CONCLUSION: Wide excision of atypical and malignant AME is recommended as local recurrence when excised completely was not observed. Given metastatic potential of malignant AME, multimodal therapy may be warranted.
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Authors | Naomi Wiens, Daniel I Hoffman, Cassie Ye Huang, Anupma Nayak, Julia Tchou |
Journal | American journal of surgery
(Am J Surg)
Vol. 219
Issue 4
Pg. 651-654
(04 2020)
ISSN: 1879-1883 [Electronic] United States |
PMID | 30982573
(Publication Type: Journal Article)
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Copyright | Copyright © 2019. Published by Elsevier Inc. |
Topics |
- Adenomyoepithelioma
(pathology, therapy)
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Breast Neoplasms
(pathology, therapy)
- Carcinoma, Ductal, Breast
(pathology, therapy)
- Female
- Follow-Up Studies
- Humans
- Mastectomy
- Mastectomy, Segmental
- Middle Aged
- Neoplasms, Multiple Primary
(pathology, therapy)
- Radiotherapy, Adjuvant
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