Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: A total of 625 examinees of regional medical checkup programs were recruited to this cross-sectional study. ClinPNs were diagnosed by the Toronto Consensus. NCA was judged by at least one bilateral abnormality of sural nerve action potential amplitude or conduction velocity measured by a point-of-care nerve conduction device (DPNCheck). Clinical factors associated with ClinPNs or NCA were examined by multiple logistic regression analysis. Deteriorating factors of sural nerve action potential amplitude or conduction velocity values were also investigated in participants without diabetes (n = 550). RESULTS: As for glucose tolerance, ClinPNs or NCA significantly increased only in known diabetes patients compared with other groups. There was no difference between prediabetes and the normal group. The prevalence of ClinPNs and NCA was not significantly related to MetS or MetS' components, except for frequent NCA in obesity. The factors significantly associated with both NCA and ClinPNs were smoking and known diabetes. In non-diabetic participants, aging, tall height and hypertension were significant deteriorating factors of nerve conduction functions. CONCLUSIONS: In Japan, ClinPNs and NCA were increased in known diabetes patients, but did not increase in participants with prediabetes, MetS and MetS' components. Smoking and known diabetes were factors significantly associated with ClinPNs or NCA. Hypertension might be a modifiable deteriorating factor of nerve function.
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Authors | Seigo Kurisu, Hideyuki Sasaki, Shohei Kishimoto, Kazuhiro Hirayasu, Kinichi Ogawa, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo, Takashi Akamizu |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 10
Issue 6
Pg. 1565-1575
(Nov 2019)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 30980464
(Publication Type: Journal Article)
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Copyright | © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
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Topics |
- Adult
- Aged
- Biomarkers
(analysis)
- Blood Glucose
(analysis)
- Cross-Sectional Studies
- Diabetes Mellitus
(physiopathology)
- Female
- Follow-Up Studies
- Humans
- Japan
(epidemiology)
- Male
- Metabolic Syndrome
(physiopathology)
- Middle Aged
- Polyneuropathies
(epidemiology)
- Prediabetic State
(physiopathology)
- Prevalence
- Prognosis
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