Maintenance treatment with trofosfamide in patients with primary bone ewing sarcoma - single center experience.

Abstract

OBJECTIVE:

Background: Patients with Ewing sarcoma have a dismal outcome. Maintenance treatment with trofosfamide has been proposed as an effective regimen for some paediatric malignancies. Aim: We sought to evaluate the schedule of trofosfamide for patients with high-risk primary bone Ewing sarcoma.

PATIENTS AND METHODS:

Materials and methods: Fifteen patients with primary bone Ewing sarcoma received treatment with trofosfamide (150 mg/m2 p.o. days 1-10) every 28 days. All patients had standard tumour imaging and laboratory evaluation. All toxicities were documented.

RESULTS:

Results: A total of 90 cycles (median 5 cycles/patient) were administered. A complete response was maintained in nine patients, while six patients had disease progression during treatment. Median time to progression was 1.9 months (range 1.8 to 4.6). Eleven patients (73.3%) are alive including nine with no evidence of disease with a median follow-up of 3.9 years (range 1.4 to 7.6). All patients with active disease at the start of the trofosfamide treatment died. There were no significant toxicities.

CONCLUSION:

Conclusions: Treatment with trofosfamide is well-tolerated and could have a role to maintain response in patients with primary bone Ewing sarcoma. Further studies are needed to better define the use of this regimen in the upfront management of those patients.

• Authors: Anna Raciborska, Katarzyna Bilska, Carlos Rodriguez-Galindo
• Journal: Developmental period medicine (Dev Period Med) Vol. 23 Issue 1 Pg. 39-44 ( 2019) ISSN: 2354-0060 [Electronic] Poland
• PMID: 30954980 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Cyclophosphamide
• trofosfamide

Topics

• Adolescent
• Antineoplastic Agents, Alkylating (adverse effects, therapeutic use)
• Bone Neoplasms (diagnosis, diagnostic imaging, drug therapy)
• Child
• Child, Preschool
• Cyclophosphamide (adverse effects, analogs & derivatives, therapeutic use)
• Female
• Humans
• Male
• Sarcoma, Ewing (diagnosis, diagnostic imaging, drug therapy)
• Treatment Outcome
• Young Adult