Hemoglobin Concentration Affects Hypertensive Basal Ganglia Hemorrhage After Surgery: Correlation Analysis in a High-Altitude Region.

Abstract

OBJECTIVE:

Hypertensive cerebral hemorrhage leads to greater mortality and worse functional outcomes at high altitudes. Experimental studies have suggested that hemoglobin can lead to increased perihemorrhagic edema after intracerebral hemorrhage.

METHODS:

Patients were divided into a high-hemoglobin (H-H) group (>180 g/L) and a low-hemoglobin (L-H) group (≤180 g/L). The distance from the cortex to the midline was used to indicate the degree of edema. At 1, 7, 14, and 21 days, the patients' status was scored using the Glasgow coma scale, and survival was plotted using Kaplan-Meier survival curves. Pearson correlation analysis showed that the difference between the postoperative and preoperative Glasgow coma scale score correlated with the hemoglobin concentration. The Glasgow outcome scale was used to assess neurological recovery after 6 months.

RESULTS:

On days 7, 14, and 21, the edema of the H-H group was significantly greater than that of the L-H group (P < 0.01 and P < 0.001, respectively). The edema of the H-H group peaked at 14 and 21 days, but that of the L-H group peaked at 7 days. The hemoglobin concentration and postoperative neurological recovery had a linear relationship in the H-H group. The L-H group had greater survival compared with the H-H group (P < 0.05). The L-H group had higher Glasgow outcome scale scores compared with the H-H group (P < 0.05).

CONCLUSION:

The hemoglobin concentration affects the mortality and morbidity from hypertensive cerebral hemorrhage in high-altitude regions, and a linear relationship exists between hemoglobin concentration and neurological recovery in the H-H group.

• Authors: Linjie Wei, Jianbo Zhang, Junjun Geng, Chi Lin, Yu Zhang, Bo Zhang, Qiang Tan, Yihao Tao, Dongping Ye, Zhi Chen, Hua Feng, Gang Zhu
• Journal: World neurosurgery (World Neurosurg) Vol. 127 Pg. e835-e842 (Jul 2019) ISSN: 1878-8769 [Electronic] United States
• PMID: 30954736 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Hemoglobins

Topics

• Aged
• Altitude
• Basal Ganglia Hemorrhage (blood, surgery)
• Cerebral Hemorrhage (surgery)
• Hemoglobins (biosynthesis)
• Humans
• Hypertension (etiology)
• Intracranial Hemorrhage, Hypertensive (blood, surgery)
• Male
• Middle Aged