Abstract |
The nepenthes-inspired slippery liquid-infused surface has led to multiple potentials in biomedical devices' design. This study aims to develop a biomimetic, environmentally-friendly slippery layer of oil-infused 3D printed polydimethylsiloxane with anti-bacterial nanosilver (iPDMS/AgNPs) for wound dressing. The engineered 3D printed iPDMS can cater the different requirements of wounds with antifouling, anti-blood staining, and kill bacteria. iPDMS/AgNPs not only exhibits biocompatibility, against adherence and effective antibacterial activity but also effectively promotes neo-epithelial and granulation tissue formation to accelerate wound healing in vivo. Optimized rheologic parameters were obtained for the 3D printable iPDMS pre-polymerization condition. Scanning electronic micrograph (SEM) and Energy Dispersive Spectrometer (EDS) show a uniform mesh with AgNPs dotted on the printed dressing. No cytotoxicity of iPDMS/AgNPs has been found via cell Counting Kit-8(CCK-8) assay. Meanwhile, the membranes infused with silicon oil effectively prevented from the adherence of the two standard drug-resistant bacteria, Staphylococcus aureus and Escherichia coli (PDMS vs. PDMS+oil, p < 0.05; PDMS+0.5%AgNPs vs. iPDMS+0.5%AgNPs, p < 0.05; PDMS+2.5%AgNPs vs. iPDMS+2.5%AgNPs, p < 0.05). By bacteria co-culture model iPDMS/AgNPs can kill about 80% of Staphylococcus aureus and Escherichia coli. When applied to a full-thickness wound defect model of murine, iPDMS/AgNPs was effective in anti- infection. It also promotes the epithelialization, the granulation tissue formation, and wound healing. These findings demonstrate that iPDMS/AgNPs may have therapeutic promise as an ideal wound dressing shortly.
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Authors | Gaoqiang Shi, Yitian Wang, Soroosh Derakhshanfar, Kaige Xu, Wen Zhong, Gaoxing Luo, Tengfei Liu, Ying Wang, Jun Wu, Malcolm Xing |
Journal | Materials science & engineering. C, Materials for biological applications
(Mater Sci Eng C Mater Biol Appl)
Vol. 100
Pg. 915-927
(Jul 2019)
ISSN: 1873-0191 [Electronic] Netherlands |
PMID | 30948128
(Publication Type: Journal Article)
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Copyright | Copyright © 2019. Published by Elsevier B.V. |
Chemical References |
- Anti-Bacterial Agents
- Dimethylpolysiloxanes
- Ions
- Oils
- Silver
- baysilon
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Bacterial Adhesion
(drug effects)
- Biofouling
- Biomimetics
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Dimethylpolysiloxanes
(pharmacology)
- Disease Models, Animal
- Escherichia coli
(drug effects)
- Fibroblasts
(cytology, drug effects)
- Granulation Tissue
(drug effects, pathology)
- Ions
- Mice, Inbred BALB C
- Microbial Sensitivity Tests
- Nanocomposites
(chemistry, ultrastructure)
- Oils
(chemistry)
- Printing, Three-Dimensional
- Rheology
- Silver
(chemistry)
- Spectroscopy, Fourier Transform Infrared
- Staphylococcus aureus
(drug effects)
- Temperature
- Wound Healing
(drug effects)
- Wound Infection
(drug therapy, pathology)
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