The change in liver stiffness, controlled attenuation parameter and fibrosis-4 index for chronic hepatitis C patients with direct-acting antivirals.

Abstract

BACKGROUND AND AIM:

Transient elastography and fibrosis-4 index (FIB-4) have been proposed to access hepatic fibrosis and steatosis for patients with chronic liver disease. This study was to determine the changes of liver stiffness (LS), controlled attenuation parameter (CAP) value and FIB-4 and their associated factors for chronic hepatitis C (CHC) patients who underwent direct-acting antivirals (DAAs).

PATIENTS AND METHODS:

Consecutive patients with CHC in advanced fibrosis or compensated cirrhosis undergoing paritaprevir/ritonavir/ombitasvir plus dasabuvir therapy and with LS and CAP before and 12 weeks after treatment were enrolled. The demographics, clinical characteristics and treatment outcomes were reviewed. The changes of LS, FIB-4, CAP and their associated factors were analyzed.

RESULTS:

A total of 213 patients (mean age: 63.7 years) with complete recommended treatment were enrolled. All patients achieved sustained virological response at 12 weeks (SVR12) of follow-up. The mean values of LS, CAP and FIB-4 index before treatment were 18.5kPa, 283dB/m and 5.05 respectively. While there was no significant change in CAP, LS and FIB-4 decreased significantly at the time of SVR12 (p<0.001). Compared with follow-up period, LS and FIB-4 decreased rapidly during DDAs. Multivariate analysis showed that higher baseline LS and FIB-4 were associated with greater reductions at the time of SVR12.

CONCLUSION:

For CHC patients in advanced fibrosis or compensated cirrhosis, DAAs improved LS and FIB-4 index at SVR12. Higher baseline LS and FIB-4 contributed to greater reductions. However, there was no significant change in CAP value.

• Authors: Yu-Chi Lee, Tsung-Hui Hu, Chao-Hung Hung, Sheng-Nan Lu, Chien-Hung Chen, Jing-Houng Wang
• Journal: PloS one (PLoS One) Vol. 14 Issue 4 Pg. e0214323 ( 2019) ISSN: 1932-6203 [Electronic] United States
• PMID: 30939158 (Publication Type: Journal Article)

Chemical References

• Anilides
• Antiviral Agents
• Carbamates
• Cyclopropanes
• Lactams, Macrocyclic
• Macrocyclic Compounds
• Sulfonamides
• ombitasvir
• Uracil
• Proline
• 2-Naphthylamine
• dasabuvir
• Transaminases
• Valine
• Ritonavir
• paritaprevir

Topics

• 2-Naphthylamine
• Adult
• Anilides (administration & dosage)
• Antiviral Agents (administration & dosage)
• Carbamates (administration & dosage)
• Cyclopropanes
• Female
• Genotype
• Hepacivirus (drug effects, pathogenicity)
• Hepatitis C, Chronic (drug therapy, genetics, physiopathology, virology)
• Humans
• Lactams, Macrocyclic
• Liver (drug effects, virology)
• Liver Cirrhosis (drug therapy, genetics, physiopathology, virology)
• Macrocyclic Compounds (administration & dosage)
• Male
• Middle Aged
• Proline (analogs & derivatives)
• Ritonavir (administration & dosage)
• Sulfonamides (administration & dosage)
• Sustained Virologic Response
• Transaminases (genetics)
• Treatment Outcome
• Uracil (administration & dosage, analogs & derivatives)
• Valine