1H NMR-based metabolomic study of metabolic profiling for pollinosis.

Abstract

BACKGROUND:

Allergic rhinitis is the main symptom of pollinosis, relieved by non-specific treatment universally. This study aimed to find the changes of serum metabolites between the seizure and remission periods of pollinosis and provide assistance in the diagnosis and/or therapy.

METHODS:

Metabonomics based on 1H nuclear magnetic resonance (NMR) was used to study the 37 serum samples of pollinosis patients.

RESULTS:

We believed that the decreased levels of isoleutine, leutine, valine, 3-hydroxybutyric acid, allo-threonine, alanine, methionine, glutamine, lysine, glycine, l-tyrosine, histidine, phenylalanine, lactate, acetate, O-acetylcholine, creatine and creatinine and the increased level of N-acetylglutamine at the seizure stage were statistically significant.

CONCLUSIONS:

Pollinosis could change the metabolic profiles of energy, amino acid and lipid in patients, which might be the diagnosis and/or prognosis markers for hay fever patients.

• Authors: Yan-Jun Zhou, Li-Sha Li, Jin-Lu Sun, Kai Guan, Ji-Fu Wei
• Journal: The World Allergy Organization journal (World Allergy Organ J) Vol. 12 Issue 1 Pg. 100005 ( 2019) ISSN: 1939-4551 [Print] United States
• PMID: 30937130 (Publication Type: Journal Article)