Lower prevalence of non-cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility.

Abstract

OBJECTIVE:

To study whether there is a difference in the prevalence of non-cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI).

DESIGN:

A secondary analysis of data from three randomized clinical trials.

SETTING:

Academic health centers.

PATIENT(S):

A total of 2,249 patients with normal uterine cavities.

INTERVENTIONS(S):

None.

MAIN OUTCOME MEASURE(S):

The presence or absence of non-cavity-distorting fibroids.

RESULT(S):

Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non-cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7% vs. 12.4%); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non-cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups.

CONCLUSION(S):

A lower prevalence of non-cavity-distorting uterine fibroids was found in infertile women with PCOS than in those with UI.

• Authors: Hao Huang, Hongying Kuang, Fangbai Sun, Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter R Casson, Gregory M Christman, Karl R Hansen, Nanette Santoro, Esther Eisenberg, Heping Zhang, Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network
• Journal: Fertility and sterility (Fertil Steril) Vol. 111 Issue 5 Pg. 1011-1019.e1 (05 2019) ISSN: 1556-5653 [Electronic] United States
• PMID: 30926125 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2019 American Society for Reproductive Medicine. All rights reserved.

Topics

• Adult
• Black People (genetics)
• Double-Blind Method
• Female
• Humans
• Infertility, Female (diagnosis, epidemiology, genetics)
• Leiomyoma (diagnosis, epidemiology, genetics)
• Polycystic Ovary Syndrome (diagnosis, epidemiology, genetics)
• Prevalence