Are extra-spinal symptoms associated with quality of life in patients with axial spondyloarthritis? A 1-year follow-up study.

Abstract

To assess the extent to which a history of extra-spinal symptoms (including peripheral arthritis, heel enthesitis, or dactylitis) (HPED) is associated with quality of life (QoL) in patients with axial spondyloarthritis (axSpA) at baseline and 1-year follow-up. We analyzed data from 138 patients with axSpA from a tertiary referral center in Singapore, seen between 2011 and 2015. Demographic, clinical variables, and patient-reported outcomes [Ankylosing Spondylitis Quality of Life (ASQoL) and SF-36] at baseline and 1-year follow-up were collected. We used linear mixed models to assess the association of HPED with QoL at baseline and 1 year post-baseline. Among 138 patients (mean age 39.3 years, 74.6% males, 87.6% Chinese, disease duration 7.4 years), at baseline, HPED was associated with poorer QoL for 3 of 8 SF-36 domains [role physical (RP) scores β - 8.38, p < 0.05; social functioning (SF) scores β - 6.74, p < 0.05; role emotional (RE) scores β - 9.37, p < 0.01] and SF-36 Physical Component Summary (PCS) (β - 4.52, p < 0.01) scores, but not ASQoL scores. At 1 year post-baseline, HPED was associated with poorer ASQoL (β 1.61, p < 0.05) scores, SF-36 PCS (β - 5.61, p < 0.01) scores, and three out of eight SF-36 domains (physical functioning (PF) β - 9.60, p < 0.01; RP β - 12.17, p < 0.01; RE β - 7.87, p < 0.05) scores. HPED was associated with QoL in patients with axSpA. After 1-year, patients with HPED have poorer QoL especially for physical health domains than patients without HPED.

• Authors: Yu Heng Kwan, Warren Fong, Ying Ying Leung, Nai Lee Lui, Chuen Seng Tan, Rahul Malhotra, Truls Østbye, Julian Thumboo
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 38 Issue 7 Pg. 1881-1887 (Jul 2019) ISSN: 1434-9949 [Electronic] Germany
• PMID: 30903309 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Female
• Follow-Up Studies
• Humans
• Linear Models
• Male
• Middle Aged
• Multivariate Analysis
• Patient Reported Outcome Measures
• Psychiatric Status Rating Scales
• Quality of Life (psychology)
• Registries
• Severity of Illness Index
• Singapore
• Spine (physiopathology)
• Spondylarthritis (physiopathology, psychology, therapy)
• Young Adult