Effect of Au-197 nanoparticles along with Sm-153 radiopharmaceutical in prostate cancer from simulation method.

Abstract

AIMS:

Based on recent studies, it was indicated that gold (Au-197) nanoparticles could be safely prescribed and used to enhance the absorbed dose during radiation therapy.

SUBJECTS AND METHODS:

We evaluated the samarium-153 (Sm-153) radiopharmaceutical and Au-197 and Sm-153 radiopharmaceutical absorbed dose rate by means of the Monte Carlo technique in prostate cancer.

RESULTS:

The results show that absorbed dose rate in entire prostate volume due to 20 mCi of Sm-153 radiopharmaceutical is 27.339 μGy/s, 48.837 μGy/s, and 76.176 μGy/s for γ-interaction, β¯ particle interaction, and γ+β¯ interaction, respectively. The results in the exterior of the prostate for β¯ interaction, β¯ particle interaction, and γ+β¯ interaction were 20.971 μGy/s, 1.110 μGy/s, and 22.081 μGy/s, respectively.

CONCLUSIONS:

The calculation results for Au-197 and Sm-153 radiopharmaceutical show that the absorbed dose rate in entire prostate volume 3% was increased and undesirable dose value in exterior of prostate 7% was decreased.

• Authors: Akbar Abbasi, Fahreddin Sadikoglu, Mostafa Hassanzadeh
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 15 Issue Supplement Pg. S42-S46 (Mar 2019) ISSN: 1998-4138 [Electronic] India
• PMID: 30900619 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Gold Colloid
• Radioisotopes
• Radiopharmaceuticals
• Samarium
• Samarium-153

Topics

• Chemoradiotherapy (methods)
• Drug Combinations
• Gold Colloid (administration & dosage)
• Humans
• Male
• Metal Nanoparticles (administration & dosage)
• Models, Biological
• Monte Carlo Method
• Prostate (drug effects, radiation effects)
• Prostatic Neoplasms (therapy)
• Radioisotopes (administration & dosage)
• Radiopharmaceuticals (administration & dosage)
• Radiotherapy Dosage
• Samarium (administration & dosage)