An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head.
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| Abstract |
Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Porous tantalum and a Bio-Gide collagen membrane, co-cultured with bone marrow mesenchymal stem cells (BMSCs) in vitro, were implanted into the defect zone to repair the full-thickness articular defect. Hyaline cartilage was detected on top of the tantalum near the edge of the defect 12 weeks post-operatively. Porous tantalum and a Bio-Gide collagen membrane with BMSCs may repair full-thickness articular defects if the blood supply can be reconstructed in the post-collapse stage of ONFH.
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| Authors | Baoyi Liu, Fan Yang, Xiaowei Wei, Xiuzhi Zhang, Yu Zhang, Benjie Wang, Ge Liu, Hui Xie, Jiahui Yang, Wei Wang, Kairong Qin, Dewei Zhao |
| Journal | Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 99 Pg. 1123-1132 (Jun 2019) ISSN: 1873-0191 [Electronic] Netherlands |
| PMID | 30889646 (Publication Type: Journal Article) |
| Copyright | Copyright © 2019. Published by Elsevier B.V. |
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